HORDB

ID: hor005293
Uniprot ID: P41337
Protein name: Pancreatic hormone
Gene name: PPY
Organism: Larus argentatus (Herring gull)
Family: NPY family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Larus (genus), Laridae (family), Charadriiformes (order), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P41337-F1.pdb

hor005293_AF2.pdb

hor005293_ESM.pdb

Mass:	486114	Formula:	C191H284N52O58
Absent amino acids:	CIKMSW	Common amino acids:	V
pI:	4.59	Basic residues:	4
Polar residues:	10	Hydrophobic residues:	10
Hydrophobicity:	-79.17	Boman Index:	-8508
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	75.56
Instability Index:	6216.39	Extinction Coefficient cystines:	5960
Absorbance 280nm:	170.29

PubMed ID: 8174930
Title: Isolation and structural characterisation of herring gull (Larus argentatus) pancreatic polypeptide.